Cryo- EM breaks 2 Ångström Barrier


Atomic Resolution Cryo-EM Structure of β-Galactosidase, Bartesaghi et al.

Cryo-electron microscopy (EM) approaches enable determination of structures of a variety of protein complexes at near-atomic resolution. These advances help to determine a cryo-EM density map for β-galactosidase bound to the inhibitor phenylethyl β-D-thiogalactopyranoside where the ordered regions are resolved at a level of detail seen in X-ray maps at ∼ 1.5 Å resolution. Using this density map in conjunction with constrained molecular dynamics simulations provides a measure of the local flexibility of the non-covalently bound inhibitor and offers further opportunities for structure-guided inhibitor design.

Your Phd

The environment of the Vienna Biocenter provides the students with the opportunity to widen their perspective on science and discover new topics that are amenable to investigation by structural biological techniques.